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  Access statistics : Table of Contents
   2008| May-August  | Volume 1 | Issue 2  
    Online since April 26, 2018

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THl/TH2 cytokine fingerprinting for probing diseases: from the bench to the clinic
Mohamed L Salem, David J Cole
May-August 2008, 1(2):21-27
Cytokines play crucial roles in all aspects of health and diseases. They influence immune expression, the development of immunologic memory, and regulation of antigen-specific and nonspecific immune activation. Based on their production by T helper (TH) cells, cytokines are categorized into TH1 and TH2 types. TH1 type includes inflammatory cytokines and growth factors. The former induces signal three that bridge innate and adaptive immunity, whilst the latter sustains proliferation and survival of T cells. Therefore, TH1 cytokines profoundly mediate generation of preventive immune responses toward infectious diseases and cancer. By contrast, TH2 cytokines are anti-inflammatory through suppression of THl-mediated immune responses, but they also accelerate TH2-mediated diseases. This article describes the impact of the THl/TH2 cytokines on shaping the nature of the immune cell responses to inflammation, infection, and cancer. We predict that THl/TH2 could be considered as a fingerprint for probing the identity of diseases. Fundamental knowledge of the design of cytokine-based therapeutic strategies is now reaching the phase of application and a number of cytokines are already on the market and many others are under clinical investigation.
[ABSTRACT]   Full text not available  [PDF]
  280 25 -
Management of Febrile Neutropenia
Michael Ellis
May-August 2008, 1(2):10-30
Full text not available  [PDF]
  157 42 -
Catheter ablation for atrial fibrillation: an update
Alawi A Alsheikh-Ali
May-August 2008, 1(2):6-9
Full text not available  [PDF]
  158 32 -
Molecular and cellular aspects of plasticity after neural injury
YS Chan, LW Chen, K.K.L Yunge, D K Y Shum
May-August 2008, 1(2):33-39
Full text not available  [PDF]
  144 32 -
Familial recurrence of sudden infant death
Michael A Patton
May-August 2008, 1(2):3-5
Full text not available  [PDF]
  146 26 -
Senile osteoporosis: does it really exist?
Gustavo Duque
May-August 2008, 1(2):28-32
Full text not available  [PDF]
  144 24 -