• Users Online: 173
  • Print this page
  • Email this page
Year : 2016  |  Volume : 9  |  Issue : 1  |  Page : 17-37

Principles of lung cancer screening – exhaled breath analysis

Otto Wagner Hospital, Vienna, Austria

Correspondence Address:
Beatrice Alexandra Marzluf
Otto Wagner Hospital, 2 Sanatoriumstrasse, 1145 Vienna
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.7707/hmj.633

Rights and Permissions

This review considers exhaled breath analysis, a non-invasive, widely applicable and cost-effective technique that holds great potential for evolving into a future screening tool for lung cancer and other diseases. Exhaled human breath contains thousands of volatile and non-volatile chemical compounds, which are products of metabolic processes and subject to changes in composition and concentration as a result of carcinogenesis. In the last decade, the analysis of volatile organic compounds (VOCs) has gained increasing interest because of the development of new technologies that might allow for detection of certain VOC biomarkers or patterns indicative of lung cancer. We provide an overview of the chemical analytical and sensor array technologies currently available for VOC analysis, including statistical methods implemented for the analysis of complex VOC patterns, and discuss issues of exhaled breath sampling and storage. Furthermore, we summarize the literature on exhaled breath analysis in lung cancer and discuss the results, limitations and future perspectives. We also briefly review the literature on sniffer dogs trained to detect lung cancer from human breath samples. In conclusion, even though certain issues have yet to be addressed and large randomized blinded studies are still lacking, there is evidence that exhaled breath analysis may be a promising tool for lung cancer screening.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded46    
    Comments [Add]    

Recommend this journal