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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 62-72

Clinical applications of amphibian antimicrobial peptides

1 Department of Biochemistry, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, U.A.E
2 Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, U.A.E

Correspondence Address:
J Michael Conlon
Department of Biochemistry Faculty of Medicine and Health Sciences United Arab Emirates University 17666, Al-Ain
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Source of Support: None, Conflict of Interest: None

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Frog skin constitutes a rich source of peptides with broad spectrum antimicrobial activity against strains of antibioticresistant bacteria and fungi and several hundred such peptides from diverse species have been described. However, their therapeutic potential remains to be realized and no anti-infective peptide based upon their structures has yet been adopted in clinical practice. This review assesses potential clinical applications of nine antimicrobial peptides isolated from frog skin (alyteserin-1c, ascaphin-8, brevinin-1BYa, brevinin-2PRa, brevinin-2-related peptide, brevinin-2-related peptide-ERa, kassinatuerin-1, pseudin-2, and temporin-DRa). The multidrugresistant microorganisms targeted include the Gramnegative bacteria Acinetobacter baumannii, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa, the Gram-positive bacterium Staphylococcus aureus, and the opportunistic yeast pathogens Candida spp. Although the naturally occurring peptides show varying degrees of cytotoxicity towards mammalian cells such as erythrocytes, analogs have been developed that retain high antimicrobial potency but are non-hemolytic. Treatment and prevention of acne and periodontal disease are identified as areas in which frog skin antimicrobial peptides might find future applications.

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