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  Indian J Med Microbiol
 

Figure 2: The mechanism of small-interfering ribonucleic acid action. Long double-stranded ribonucleic acid is introduced to a cell. Once it is in the cytoplasm, the dicer enzyme cleaves the double-stranded ribonucleic acid into small-interfering ribonucleic acid with 2 nucleotide 3' overhangs. Following cleavage, ribonucleic acid-induced silencing complex loads and unwinds the small-interfering ribonucleic acid, and binds to the complementary target mRNA which is subsequently cleaved by the ribonucleic acid-induced silencing complex. Following cleavage, the ribonucleic acid-induced silencing complex disassembles and is ready to generate another small-interfering ribonucleic acid for cleavage of additional mRNA[18]

Figure 2: The mechanism of small-interfering ribonucleic acid action. Long double-stranded ribonucleic acid is introduced to a cell. Once it is in the cytoplasm, the dicer enzyme cleaves the double-stranded ribonucleic acid into small-interfering ribonucleic acid with 2 nucleotide 3' overhangs. Following cleavage, ribonucleic acid-induced silencing complex loads and unwinds the small-interfering ribonucleic acid, and binds to the complementary target mRNA which is subsequently cleaved by the ribonucleic acid-induced silencing complex. Following cleavage, the ribonucleic acid-induced silencing complex disassembles and is ready to generate another small-interfering ribonucleic acid for cleavage of additional mRNA<sup>[18]</sup>