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  Indian J Med Microbiol
 

Figure 5: Schematic model showing STZ cytotoxicity targets and its prevention by NAC in Rin-5F cells. STZ and glucose enter the cells causing increased oxidative stress, increased ROS production and DNA damage, which in turn lead to apoptosis. STZ also causes increased apoptosis via caspase-8 activation. NAC attenuates the effects of STZ-induced toxicity. Bold upward arrows indicate increase while bold crosses represent prevention. NAC: N-acetyl cysteine, STZ: Streptozotocin, ROS: Reactive oxygen species

Figure 5: Schematic model showing STZ cytotoxicity targets and its prevention by NAC in Rin-5F cells. STZ and glucose enter the cells causing increased oxidative stress, increased ROS production and DNA damage, which in turn lead to apoptosis. STZ also causes increased apoptosis via caspase-8 activation. NAC attenuates the effects of STZ-induced toxicity. Bold upward arrows indicate increase while bold crosses represent prevention. NAC: N-acetyl cysteine, STZ: Streptozotocin, ROS: Reactive oxygen species