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  Indian J Med Microbiol
 

Figure 5: Regions of differences in gray matter volume in medication-naïve participants with major depressive disorder. (a) The axial image (Z = 8 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly decreased gray matter volume in right dorsolateral prefrontal cortex in medication-naïve participants with major depressive disorder, compared to healthy controls (P < 0.05, corrected). (b) The axial image (Z = 42 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly decreased gray matter volume in left middle frontal gyrus in medication-naïve participants with major depressive disorder, compared to healthy controls (P < 0.05, corrected). (c) The axial image (Z = 11 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly increased gray matter volume in left thalamus in medication-naïve participants with major depressive disorder, compared to healthy controls (P < 0.05, corrected). (d) The axial image (Z = 3 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly increased gray matter volume in right insula in medication-naïve participants with major depressive disorder, compared to healthy controls (P < 0.05, corrected). The color bar represents the range of T values. R = right[40]

Figure 5: Regions of differences in gray matter volume in medication-naïve participants with major depressive disorder. (a) The axial image (<i>Z</i> = 8 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly decreased gray matter volume in right dorsolateral prefrontal cortex in medication-naïve participants with major depressive disorder, compared to healthy controls (<i>P</i> < 0.05, corrected). (b) The axial image (<i>Z</i> = 42 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly decreased gray matter volume in left middle frontal gyrus in medication-naïve participants with major depressive disorder, compared to healthy controls (<i>P</i> < 0.05, corrected). (c) The axial image (<i>Z</i> = 11 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly increased gray matter volume in left thalamus in medication-naïve participants with major depressive disorder, compared to healthy controls (<i>P</i> < 0.05, corrected). (d) The axial image (<i>Z</i> = 3 mm Montreal Neurological Institute coordinate plane) shows the regions of significantly increased gray matter volume in right insula in medication-naïve participants with major depressive disorder, compared to healthy controls (<i>P</i> < 0.05, corrected). The color bar represents the range of T values. <i>R</i> = right<sup>[40]</sup>