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Haemophagocytic lymphohistiocytosis and the challenge of early diagnosis


1 Department of Internal Medicine, Hatta Hospital, Dubai, UAE
2 Department of Haematology, Dubai Hospital, Dubai, UAE
3 Department of Intensive Care, Hatta Hospital, Dubai, UAE

Correspondence Address:
Hoda Mohamed Hammoda,
Department of Internal Medicine, Hatta Hospital, Dubai
UAE
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2227-2437.237849

Haemophagocytic lymphohistiocytosis (HLH) is an uncommon, life-threatening hyperinflammatory syndrome in which abnormal, ineffective energising of the immune system causes excessive activation of lymphocytes and macrophages, which can lead to hypercytokinaemia and massive tissue destruction. A high index of suspicion is necessary for early diagnosis. We report a case of HLH in a 66-year-old woman who presented with fever, pancytopenia and hepatosplenomegaly.


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    -  Hammoda HM
    -  Marashi MM
    -  Mohamed Abdalla HA
    -  Awad Makhlof ME
    -  Rezzek MS
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