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CASE REPORT
Year : 2018  |  Volume : 11  |  Issue : 1  |  Page : 40-41

Rare complications of severe mucositis and psychosis with levetiracetam in an emirati child with acute lymphoblastic leukaemia


Department of Pediatric Hematology-Oncology, Dubai Hospital, Dubai, United Arab Emirates

Correspondence Address:
Dr. Anjan Madasu
Paediatric Haematology Oncology Unit, Dubai Hospital, Dubai
United Arab Emirates
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Source of Support: None, Conflict of Interest: None


DOI: 10.7707/hmj.741

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We report on a 10-year-old Emirati child with T-cell acute lymphoblastic leukaemia who developed severe mucositis and psychosis while taking levetiracetam. The child was diagnosed with T-cell acute lymphoblastic leukaemia on 9 May 2014 and was started on chemotherapy in accordance with the ALL-BFM 95 protocol. During induction chemotherapy, he developed seizures thought to be due to posterior reversible encephalopathy syndrome, and after neurology consultation, he was started on levetiracetam. He developed severe mucositis and psychosis while on levetiracetam, which was resolved by discontinuing treatment with this medication. Levetiracetam has been used to treat seizures in children with cancer because of its low reported side effects and compatibility with chemotherapy. Severe mucositis and psychosis are two serious complications associated with levetiracetam. This is the first reported case in the literature of an Emirati child with leukaemia developing severe mucositis and psychosis when taking levetiracetam.


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