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REVIEW FOR THE SHEIKH HAMDAN BIN RASHID AL MAKTOUM AWARD FOR MEDICAL SCIENCES
Year : 2014  |  Volume : 7  |  Issue : 3  |  Page : 403-409

Antiproliferative and pro-apoptotic actions of oestrogen receptor β in prostate cancer


Center for Nuclear Receptors and Cell Signaling, Department of Biochemistry and Biology, University of Houston, Houston, TX, USA

Correspondence Address:
Jan-Ake Gustafsson
Center for Nuclear Receptors and Cell Signaling, Department of Biochemistry and Biology, University of Houston, Houston, TX
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.7707/hmj.354

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Oestrogen receptor (ER) β, the second ER, appears to be a tumour suppressor in most tissues that have been investigated. Recently, studies of prostate cancer have shown that tumour-suppressive effects of ERβ occur through varying mechanisms including increased apoptosis, reduced invasiveness and epithelial mesenchymal transition as well as inhibited proliferation. It has been suggested that ERβ is a potential drug target for the treatment of prostate cancer.


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