• Users Online: 44
  • Print this page
  • Email this page
ORIGINAL RESEARCH ARTICLE
Year : 2012  |  Volume : 5  |  Issue : 2  |  Page : 179-188

Regional anaesthesia and analgesia for cancer surgery


1 Anaesthesia and Intensive Care Department, Hôpital Lapeyronie, University of Montpellier and Research Unit INSERM U1046, Montpellier, France
2 Anaesthesia Department, Rashid Hospital Trauma Centre, Dubai Health Authority, United Arab Emirates
3 Anaesthesia and Intensive Care Department SAR 3, Hospital Pellegrin University of Bordeaux and Research Unit INSERM U688, Bordeaux, France

Correspondence Address:
Xavier Capdevila
Anaesthesia and Intensive Care Department, Hôpital Lapeyronie, University of Montpellier and Research Unit INSERM U1046, Bat Crastes de Paulet, Montpellier
France
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.7707/hmj.v5i2.131

Rights and Permissions

The evolution of cancer cells in clinical metastases depends on antimetastatic immune activity and the ability of the tumour to proliferate and generate new blood vessels (neoangiogenesis). Surgery by itself can depress cellular immunity and functions of cytotoxic T lymphocytes and natural killer (NK) cells. The perioperative stress response releases tumour cells into the circulation and anaesthesia further reduces immune functions, including the functions of neutrophils, macrophages, dendritic cells, T lymphocytes and NK cells. Effective treatment of postoperative pain could play an important role in limiting the metastatic migration following oncology surgery. Opioids used intraoperatively and postoperatively inhibit cellular and humoral immune functions in humans and have natural pro-angiogenic properties. In a retrospective analysis, paravertebral anaesthesia and analgesia for breast cancer surgery reduced the risk of recurrence or metastasis by four during the first years of follow-up. Similarly, following epidural anaesthesia for resection of the prostate, biochemical recurrence of prostate cancer was reduced by 65% and, following colon surgery, the oncological prognosis was enhanced in the first two years. To date there are only retrospective clinical studies available. A prospective, randomized, large-size study focused on cancers with high risk of recurrence is needed to determine if regional anaesthesia and analgesia could have potential for clinically reducing cancer recurrence after oncology surgery.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed35    
    Printed2    
    Emailed0    
    PDF Downloaded5    
    Comments [Add]    

Recommend this journal