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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 53-61

Dental stem cells and their potential role in regenerative medicine


1 Boston University Institute of Dental Research and Education, Dubai; Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates
2 Boston University Institute of Dental Research and Education, Dubai, United Arab Emirates
3 Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates

Correspondence Address:
Sherif M Karam
Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain
United Arab Emirates
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Source of Support: None, Conflict of Interest: None


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Advances have been made in identifying dental stem cells and their differentiation potential. Five different types of dental stem cells have been isolated from dental soft tissues: dental pulp, apical papilla, dental follicle and periodontal ligament. The characteristic features of these cells have been explored. They express various arrays of biomarkers including those specific for mesenchymal and/or embryonic stem cells. In vitro and in vivo studies have revealed that these stem cells varied in their proliferation and differentiation potential. Recent studies have demonstrated their wide range of plasticity and their potential use for regenerative medicine and dentistry. This article summarizes information available on the different types of dental stem cells and discusses their potential use in regenerative medicine.


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