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REVIEW ARTICLE
Year : 2010  |  Volume : 3  |  Issue : 3  |  Page : 136-141

Natural history to molecular pathogenesis to preventive trials


Barbara Davis Center for Childhood Diabetes, University of Colorado, USA

Correspondence Address:
George S Eisenbarth
Barbara Davis Center for Childhood Diabetes University of Colorado
USA
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Source of Support: None, Conflict of Interest: None


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Humans, mice and rats are susceptible to autoimmune diabetes we believe due to common molecular sequences of the trimolecular complex targeting of insulin, when tolerance mechanisms fail. The disease is now predictable in man, preventable in animal models, and recent trials indicate the potential for preventive therapy in man.


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